Specification of the CHOReOS IDRE (D5.2)

This deliverable focuses on the design of the CHOReOS Integrated Development and Runtime Environment, aka CHOReOS IDRE, based on the supporting solutions developed within WP2, WP3 and WP4 during CHOReOS' 1st year. The document provides an overall description of the IDRE components, their respective functionalities and the integration dependencies between them, thereby defining the integration points between the components developed in WP2-3-4

ATUALIZAÇÕES DAS MANIFESTAÇÕES CLÍNICAS DA DOENÇA PULMONAR OBSTRUTIVA CRÔNICA: UMA REVISÃO INTEGRATIVA

This work aims to discuss and highlight the main clinical manifestations present in chronic obstructive pulmonary disease (COPD). The work is an integrative review, carried out through the search, in the PubMed database, of the following Descriptors in Health Sciences (DeCS): clinical; manifestations; chronic; obstructive; pulmonary; disease. Of the works found, only those published in 2023, until 08/31/2023, were selected, in which 30 articles were selected, 23 of which were excluded and 7 were analyzed for the production of the work. The clinical manifestations of COPD are multiple, with pulmonary manifestations (cough, throat clearing, shortness of breath) and extrapulmonary manifestations (anxiety and muscle weakness). From this information, it is important to make an overview of the main works on this subject to help in the therapeutic plan. Este trabalho tem o objetivo de debater e evidenciar as principais manifestações clínicas presentes na doença pulmonar obstrutiva crônica (DPOC). O trabalho trata-se de uma revisão integrativa, realizada através da busca, na base de dados PubMed, dos seguintes Descritores em Ciências da Saúde (DeCS): clinical; manifestations; chronic; obstructive; pulmonary; disease. Dos trabalhos encontrados foram selecionados apenas os publicados em 2023, até a data de 31/08/2023, em que foram selecionados 30 artigos, sendo que 23 foram excluídos e 7 foram analisados para a produção do trabalho. As manifestações clínicas da DPOC são múltiplas, possuindo manifestações pulmonares (tosse, pigarro, falta de ar) e extrapulmonares (ansiedade e fraqueza muscular), dessa forma o debate e conhecimento dessas manifestações é de extrema importância para o seguimento clínico e orientação do paciente. A partir destas informações, é importante que se faça um apanhado dos principais trabalhos acerca deste tema para o auxílio no plano terapêutico. &nbsp

Photography-based taxonomy is inadequate, unnecessary, and potentially harmful for biological sciences

The question whether taxonomic descriptions naming new animal species without type specimen(s) deposited in collections should be accepted for publication by scientific journals and allowed by the Code has already been discussed in Zootaxa (Dubois & Nemésio 2007; Donegan 2008, 2009; Nemésio 2009a–b; Dubois 2009; Gentile & Snell 2009; Minelli 2009; Cianferoni & Bartolozzi 2016; Amorim et al. 2016). This question was again raised in a letter supported by 35 signatories published in the journal Nature (Pape et al. 2016) on 15 September 2016. On 25 September 2016, the following rebuttal (strictly limited to 300 words as per the editorial rules of Nature) was submitted to Nature, which on 18 October 2016 refused to publish it. As we think this problem is a very important one for zoological taxonomy, this text is published here exactly as submitted to Nature, followed by the list of the 493 taxonomists and collection-based researchers who signed it in the short time span from 20 September to 6 October 2016

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial

Background: Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design: ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with ARDS compared to conventional treatment (ARDSNet strategy). We will enroll adult patients with ARDS of less than 72 h duration. The intervention group will receive an alveolar recruitment maneuver, with stepwise increases of PEEP achieving 45 cmH(2)O and peak pressure of 60 cmH2O, followed by ventilation with optimal PEEP titrated according to the static compliance of the respiratory system. In the control group, mechanical ventilation will follow a conventional protocol (ARDSNet). In both groups, we will use controlled volume mode with low tidal volumes (4 to 6 mL/kg of predicted body weight) and targeting plateau pressure <= 30 cmH2O. The primary outcome is 28-day survival, and the secondary outcomes are: length of ICU stay; length of hospital stay; pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; mechanical ventilation-free days from days 1 to 28; ICU, in-hospital, and 6-month survival. ART is an event-guided trial planned to last until 520 events (deaths within 28 days) are observed. These events allow detection of a hazard ratio of 0.75, with 90% power and two-tailed type I error of 5%. All analysis will follow the intention-to-treat principle. Discussion: If the ART strategy with maximum recruitment and PEEP titration improves 28-day survival, this will represent a notable advance to the care of ARDS patients. Conversely, if the ART strategy is similar or inferior to the current evidence-based strategy (ARDSNet), this should also change current practice as many institutions routinely employ recruitment maneuvers and set PEEP levels according to some titration method.Hospital do Coracao (HCor) as part of the Program 'Hospitais de Excelencia a Servico do SUS (PROADI-SUS)'Brazilian Ministry of Healt